Lithium Hydroxide → HCID 57965771, compound

Participants

Reaction Conditions

Reaction Steps

4 mg (0.17 mmol) of lithium hydroxide are added to a solution of 50 mg (0.08 mmol) of 4-[(3E)-2-{2-[1-(2-ethoxy-2-oxoethyl)cyclopropyl]ethyl}-4-(2-{[4-(trifluoromethoxy)benzyl]oxy}phenyl)-but-3-en-1-yl]benzoic acid (enantiomer 1) in 2 ml of THF and 1 ml of water, and the mixture is stirred at 50° C. for 12 hours. After cooling, the THF is removed under reduced pressure, and the aqueous phase is adjusted to pH 4 using 1 M hydrochloric acid. The product precipitates out and is filtered off, washed with water and dried. This gives 38 mg (79% of theory) of a slightly white solid.

Provenance & Evidence