HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 66873480, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | 1-(Cyanoacetyl)piperidine | HCID 84765 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66873480 | HCID 66873480 | 25% |
Reaction Steps
Methyl thiosalicylate (1.7 g, 10.1 mM) and 1-cyanoacetylpiperidine (2.0 g, 13.1 mM) were dissolved in toluene (5 ml), and triethylamine (2 ml, 14.4 mM) was added to the solution. After heating for 30 hours under reflux, the reaction solution was concentrated to give crude crystals. The crude crystals were recrystallized from ethanol to give the title compound as needles (730 mg, 25%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173360B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f60b5d4c8a654bcbb206f1fb927335d3 |
| Source note | uspto-grants-2012_05 |