HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-benzyl-L-tyrosine → (S)-3-(4-Benzyloxy-phenyl)-2-(biphenyl-3-ylamino)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-benzyl-L-tyrosine | HCID 725701 | — |
| Reactant | (S)-2-(Biphenyl-3-ylamino)-3-(3,4,5-trimethoxy-phenyl)-propionic acid | HCID 11384247 | — |
| Product | (S)-3-(4-Benzyloxy-phenyl)-2-(biphenyl-3-ylamino)-propionic acid | HCID 67492656 | — |
Reaction Steps
The title compound is prepared as described for (S)-2-(Biphenyl-3-ylamino)-3-(3,4,5-trimethoxy-phenyl)-propionic acid (example 1) but using (S)-2-Amino-3-(4-benzyloxy-phenyl)-propionic acid (O-benzyl-L-tyrosine). Purification by MPLC (CH3CN/H2O/TFA) afforded the title compound; ES-MS: 424.3 [M+H]+; HPLC: single peak at tR=10.40 min (System 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173128B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-0162508671c34f5d858e7850de245843 |
| Source note | uspto-grants-2012_05 |