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HRID1920635

反应详情

EQUATION

反应方程式

HRID 1920635 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)Cc1cccc(Oc2ccccc2)c1
HCID141749

3-Phenoxyphenylacetic acid

C14H12O3

结构：COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1OC
HCID10829890

boc-3,4-dimethoxy-l-phenylalanine

C16H23NO6

结构：CC(C)C[C@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
HCID67492646

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C[C@H](NC(=O)Cc2cccc(Oc3ccccc3)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)C(C)C)cc1OC
HCID10169507

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from {(S)-2-Methyl-1-[(R)-3-methyl-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-butylcarbamoyl]-propyl}-carbamic acid tert-butyl ester by reiteration of the 2-step (deprotection/coupling) procedure described in example 1 but using Boc-L-3,4-dimethoxyphenylalanine (Synthetech) and (3-Phenoxy-phenyl)-acetic acid (Trans World Chemicals, Inc.; Rockville, Md., USA) as the partners in each coupling reaction (step B, example 1), respectively. The title compound is obtained as a foam; ES-MS: 782.3 [M+H]+; HPLC: single peak at tR=11.76 min (System 1); Rf=0.61 (CH2Cl2/MeOH, 90/10).

WORKUP

后处理

  1. customin each coupling reaction (step B, example 1)