HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-(6-Aminopurin-9-yl)ethanol | HCID 242652 | — |
| Solvent | sodium;acetic acid;acetate | HCID 178476574 | — |
| Product | 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol | HCID 44572469 | 43% |
Reaction Steps
To a solution of 10 g 2-(6-amino-purin-9-yl)ethanol in 200 ml 0.5M AcONa/AcOH buffer pH 4 were added 4 ml of Br2. The resulting mixture was stirred at room temperature for 8 hours. The precipitated product was isolated, washed with water and crystallized from ethanol to give 6.13 g (43%) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173609B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-7c2c581a412e4451ae310470494ed016 |
| Source note | uspto-grants-2012_05 |