反应详情

0.45 g of 2-(6-amino-8-(2-pyridin-3-yl-ethyl)-purin-9-yl)ethanol were cooled to −20° C. and 6 ml of SOCl2 were added. The temperature was gradually risen to 50° C. and the mixture was stirred at this temperature for 12 hours. The excess of SOCl2 was evaporated and the residue was taken up in dichloromethane washed with saturated aqueous NaHCO3 dried over Na2SO4 and evaporated in vacuo. The crude product was purified by flash chromatography on silica gel (CHCl3:MeOH 50:1) to give 40 mg (8%) of the desired product.

1. customwas gradually risen to 50° C.
2. customThe excess of SOCl2 was evaporated
3. washwashed with saturated aqueous NaHCO3
4. dry with materialdried over Na2SO4
5. customevaporated in vacuo
6. customThe crude product was purified by flash chromatography on silica gel (CHCl3:MeOH 50:1)