Sodium Hydroxide → HCID 136360483, compound

Participants

Reaction Conditions

Reaction Steps

Referring to FIG. 19, hydroxylamine hydrochloride (0.106 g, 1.52 mmol) was added to a mixture of 6 (0.200 g, 1.06 mmol) in a solution of NaOH (0.3 in 6 mL water). The reaction was stirred at 95° C. for 15 min followed by the addition of glacial acetic acid until it reached pH 6. The resulting mixture was cooled in an ice bath and vacuum filtered to afford 7 (0.176 g, 0.869 mmol, 82% yield) as a yellow solid, which was carried to the next step without further purification.

Provenance & Evidence