Sodium borohydride → HCID 25228126, compound

HRID 1920690Notes

Reaction equation

HRID 1920690 reaction equation
[BH4-].[Na+].[CH3:3][N:4]([CH3:20])[C:5](=[O:19])[S:6][C:7]1[CH:16]=[C:15]2[C:10]([CH:11]=[CH:12][C:13]([CH:17]=[O:18])=[N:14]2)=[CH:9][CH:8]=1>C(O)C.C(Cl)(Cl)Cl>[CH3:3][N:4]([CH3:20])[C:5](=[O:19])[S:6][C:7]1[CH:16]=[C:15]2[C:10]([CH:11]=[CH:12][C:13]([CH2:17][OH:18])=[N:14]2)=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 25228498HCID 25228498, compound

Product 1

HCID 25228126HCID 25228126, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6212ChloroformSolvent

Procedure

Referring now to FIG. 22, NaBH4 (6.2 mg, 0.165 mmol) was added to a solution of 18 (43.1 mg, 0.165 mmol) in ethanol (1 mL), and the resulting mixture was stirred at room temperature. After TLC indicated the reaction was complete, the solvent was evaporated and the residue obtained was dissolved in chloroform. The solution was then washed with brine (×2), dried over Na2SO4, and evaporated to provide 19 (36.5 mg, 0.139 mmol, 85% yield) was obtained and carried to the next step without further purification.

Workup

  1. customthe solvent was evaporated
  2. customthe residue obtained
  3. washThe solution was then washed with brine (×2)
  4. dry with materialdried over Na2SO4
  5. customevaporated

Sources & evidence

ORD record
ord-902105d49ab34c579c183e9d07ea2385
Source dataset
uspto-grants-2012_05
Patent number
US08173620B2

Reaction notes

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