HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 53305814, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | ((2R,3R,4R,5R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate | HCID 53305813 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 53305814 | HCID 53305814 | — |
Reaction Steps
To a solution of mixture of compound 8 (1.0 g, 2.67 mmol) and PPh3 (1.4 g, 5.34 mmol) in CH2Cl2 (15 mL) was added NCS (1.07 g, 8.01 mmol) portionwise at 0° C. Then the resulting mixture was stirred at rt for 1 h and poured into a silica gel column and eluted with EtOAc-hexanes (1:4) using pressure. The collected right fractions were combined, concentrated, and co-evaporated with CH2Cl2 several times and used next step (1.0 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173621B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-cec614c0dd9f4fa698112bd8fa23b365 |
| Source note | uspto-grants-2012_05 |