HCID 59526803, compound → HCID 59526811, compound

Participants

Reaction Steps

A solution of (S)-1-((R)-1-benzylpyrrolidin-3-yl)-N-(2-fluoroethyl)ethanamine (0.27 g, 1.08 mmol) and palladium hydroxide (0.27 g, 20 wt. % Pd on carbon, 50% wet) in ethanol (8.0 mL) is heated at 40° C. for 15 h under an atmosphere of hydrogen, and cooled to rt. The resulting mixture is filtered through a Büchner funnel on a layer of Celite washing with methanol. The filtrate is evaporated under reduced pressure to afford the title compound in quantitative yield (0.17 g). The residue obtained is used in the next reaction without further purification.

Provenance & Evidence