HCID 59526799, compound → HCID 46941147, compound

HRID 1920706Notes

Reaction equation

HRID 1920706 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:24])=[C:11]([N:18]4[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]4)[C:12]=3[O:14][CH:15]([F:17])[F:16])[C:7](=[O:25])[C:6]([C:26]([O:28]CC)=O)=[C:5]2[SH:31])[CH2:3][CH2:2]1.[CH:32]1([N:35]2C3C(=CC(F)=C(F)C=3OC)C(=O)C3C(O)=C(C#N)SC2=3)C[CH2:33]1>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:24])=[C:11]([N:18]4[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]4)[C:12]=3[O:14][CH:15]([F:17])[F:16])[C:7](=[O:25])[C:6]3[C:26]([OH:28])=[C:33]([C:32]#[N:35])[S:31][C:5]2=3)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 59526799HCID 59526799, compoundHCID 178470128HCID 178470128, compound

Product 1

HCID 46941147HCID 46941147, compound

Procedure

The title compound is prepared from ethyl 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-2-mercapto-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate using the method described above for the preparation of 9-cyclopropyl-6,7-difluoro-3-hydroxyl-8-methoxy-4-oxo-4,9-dihydrothieno[2,3-b]quinoline-2-carbonitrile.

Sources & evidence

ORD record
ord-0efdd80acccb48c697a0d93a6205f921
Source dataset
uspto-grants-2012_05
Patent number
US08173636B2

Reaction notes

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