反应详情

0.18 g (1.20 mmol) of 2-hydroxyl-N-methylbenzenecarboximidamide is stirred with 0.48 g (2.42 mmol) of 1,1′-sulphonyldiimidazole at 120° C. for 18 hours. Cooling is followed by stirring the mixture with water and then decanting off from the water. The remaining residue is chromatographed on silica gel (450 g, 40-63 μm) with dichloromethane/methanol=99/1. 87 mg of product are isolated.

1. temperatureCooling
2. customdecanting off from the water
3. customThe remaining residue is chromatographed on silica gel (450 g, 40-63 μm) with dichloromethane/methanol=99/1