反应详情

3.65 g [20.48 mmol] of 4-ethoxy-3-amino-1,2-benzisoxazole are hydrogenated in 40 ml of methanol and in the presence of 0.39 g of palladium (loading: 10, support: activated carbon) at room temperature and pressure 1 bar for 16 hours, analogously to the method from WO 2007/030582. The reaction mixture is filtered through silica gel, and rinsed through repeatedly with methanol. The combined filtrates are concentrated under reduced pressure. This leaves 1.9 g of product as a beige solid; the purity according to LC-MS is 100%.

1. filtrationThe reaction mixture is filtered through silica gel
2. washrinsed through repeatedly with methanol
3. concentrationThe combined filtrates are concentrated under reduced pressure