HCID 58267711, compound → HCID 178466628, compound

Participants

Reaction Steps

2.75 g [14.31 mmol] of 4-ethoxy-N-methyl-1,2-benzisoxazol-3-amine are hydrogenated in 30 ml of methanol and in the presence of 0.28 g of palladium (loading: 10, support: activated carbon) at room temperature and pressure 1 bar for 16 hours, analogously to the method from WO 2007/030582. The reaction mixture is filtered through silica gel, and rinsed through repeatedly with methanol. The combined filtrates are concentrated under reduced pressure. This leaves 1.1 g of product as a grey solid; the purity is >95% according to 1H NMR.

Provenance & Evidence