反应详情

A solution of 130 mg (0.87 mmol) of 5-(1-methyl-propenyl)-pyridin-2-ylamine in ethanol (5 mL) was reduced over palladium on charcoal (10 wt %, 13 mg) under a hydrogen atmosphere at room temperature for 18 h. The catalyst was separated by filtration through Celite® and washed with ethanol (5 mL). The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica, eluent ethyl acetate) to afford 90 mg of 5-sec-butyl-pyridin-2-ylamine. ES−MS: m/z 151 [M+H+];

1. customThe catalyst was separated by filtration through Celite®
2. washwashed with ethanol (5 mL)
3. concentrationThe filtrate was concentrated under reduced pressure
4. customThe residue was purified by column chromatography (silica, eluent ethyl acetate)