HCID 57733375, compound → HCID 57733330, compound

HRID 1920750Notes

Reaction equation

HRID 1920750 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:8][CH2:7]1)[CH3:2].[H][H]>C(O)C>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:10][CH2:11]1)[CH3:2]

Participants

4

Reactant 2

HCID 57733375HCID 57733375, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57733330HCID 57733330, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (1-tert-butyl-piperidin-4-ylidene)-acetic acid ethyl ester (5.1 g, 22.7 mmol) in ethanol (50 mL) 10% Pd/C (0.6 g) was added and the mixture was stirred under the hydrogen atmosphere (42 psi) at ambient temperature for 14 hours. The catalyst was removed by filtration, and the filtrate was concentrated to give the title (4.03 g, yield 78%), which was used in the next step directly.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customto give the title (4.03 g, yield 78%), which

Sources & evidence

ORD record
ord-3fd4387adce24d1f9ff5c2e7e14fbab6
Source dataset
uspto-grants-2012_05
Patent number
US08173639B2

Reaction notes

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