Tetrahydrofuran → HCID 57733409, compound

Participants

Reaction Steps

To a stirred solution of 3-methyl-8-nitro-1-oxo-2-phenyl-1,2-dihydro-isoquinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide (1am, 10 mg, 0.023 mmol) in tetrahydrofurane (0.15 ml) 2M aq. HCl (0.12 ml, 0.25 mmol) and Zn powder (45 mg, 0.69 mmol) was added. After 30 min the mixture was filtered and partitioned between ethyl acetate (4 ml) and sat. aq. NaHCO3 (2 ml), then brine (3 ml). The organic solution was dried (MgSO4) and evaporated to afford 5.9 mg of the title compound (70% yield). LC-MS (m/z) 412.4 (MH+); tR=1.37.

Provenance & Evidence