Aniline → HCID 57733416, compound

Participants

Reaction Steps

A sealed mixture of 2-[2-oxo-1-((S)-1-phenyl-propylcarbamoyl)-butyl]-benzoic acid (82 mg, 0.2 mmol) and aniline (0.3 ml, 3.3 mmol) in acetonitrile (0.3 ml) was heated under microwave irradiation at +160° C. for 10 min. The mixture was partitioned between ethyl acetate (20 ml) and 3M aq. HCl (2×8 ml), sat. aq. NaHCO3 (2×10 ml and brine, dried (MgSO4) and evaporated. The residue was purified by flash chromatography (SiO2, gradient heptane-ethyl acetate) to give 32 mg of the title compound. LC-MS (m/z) 411.5 (MH+); tR=1.48. 1H NMR (500 MHz, DMSO-d6): a mixture of two atropisomers.

Provenance & Evidence