Sulfuryl chloride → HCID 25069587, compound

Participants

Reaction Steps

A solution of compound 12F (16.8 mg, 0.05 mmol), sulfonyl chloride (0.06 mmol) and DIEA (17.4 μl, 0.10 mmol) in CHCl3 (200 μl) was maintained at ambient temperature for 30 minutes. Solvents were removed in vacuum. Residue was dissolved in 200 μl of DMSO and subjected to HPLC purification. [Chromolith SpeedRod RP-18e C18 column (4.6×50 mm); flow rate 1.5 ml/min; mobile phase A: 0.1% TFA/water; mobile phase B 0.1% TFA/ACN; gradient elution from 5% B to 100% B over 9.5 min, detection 254 nm]. Fractions containing the desired product were combined and dried to provide trifluoroacetic salt of target product.

Provenance & Evidence