HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-butenoate → Methyl (3E)-4-(2-{(1R)-1-[(2R)-oxiran-2-yl methoxy]ethyl}phenyl)but-3-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-butenoate | HCID 77314 | — |
| Reactant | (2R)-2-[[(1R)-1-(2-bromophenyl)ethoxy]methyl]oxirane | HCID 58981243 | — |
| Product | Methyl (3E)-4-(2-{(1R)-1-[(2R)-oxiran-2-yl methoxy]ethyl}phenyl)but-3-enoate | HCID 58572466 | 65% |
Reaction Steps
By using (2R)-2-{[(1R)-1-(2-bromo phenyl)ethoxy]methyl}oxirane (257 mg, 1.00 mmol) described in WO 2004/094362 and methylbut-3-enoate, the reaction was carried out in the same manner as the method described in Example 3 (3c) to give the title compound as a yellow oily substance (yield 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173631B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e339da1dd5744781bfeabef91d7d4322 |
| Source note | uspto-grants-2012_05 |