HCID 67422430, compound → HCID 67422772, compound

Participants

Reaction Steps

Ethyl (2E)-3-{4-chloro-5-fluoro-2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl)pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoate (320 mg, 0.61 mmol) which had been obtained in Example 156 (156a) was dissolved in ethanol (20 mL), added with rhodium/alumina (96 mg), and stirred at room temperature for 45 minutes under a hydrogen atmosphere. The reaction solution was filtered through Celite. The solvent was distilled off under reduced pressure. The residue was purified by basic silica gel column chromatography (n-hexane/ethyl acetate=1/1) to give the title compound as a colorless oily substance (310 mg, yield 97%).

Provenance & Evidence