Ethanol hydrochloride → HCID 67422867, compound

Participants

Reaction Steps

By adding 2 M hydrochloric acid/ethanol solution (15 mL) to (2R,4R)-4-(benzyloxy)-2-(3-fluoro-4-methylbenzyl)pyrrolidine (1.45 g, 4.84 mmol) which had been synthesized according to Example 1 (1e)-20, a suspension was prepared. Methanol (10 mL) was added thereto to yield a homogenous solution. 20% Palladium hydroxide-carbon (wet, 50 wt %, 483 mg) was added thereto for hydrogenation under atmospheric pressure for 16 hours. The reaction solution was filtered. The solvent was distilled off under reduced pressure. The residue was added with diethyl ether to yield a suspension, which was then filtered and washed with diethyl acetate to give the title compound as a white solid (1.13 g, yield 95%).

Provenance & Evidence