HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1920823Generated: November 1, 2026
Hydrochloric Acid → N-[5-(1,6-Dihydro-4-hydroxy-6-oxo-2-pyrimidinyl)-2-pyridinyl]-2,2-dimethylpropanamide
https://huagongshe.com/reaction/1920823
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylmalonat | HCID 6946994 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 59198402 | HCID 59198402 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[5-(1,6-Dihydro-4-hydroxy-6-oxo-2-pyrimidinyl)-2-pyridinyl]-2,2-dimethylpropanamide | HCID 59198397 | — |
Reaction Steps
A suspension of sodium methoxide (432 mg, 8.0 mmol), N-(5-carbamimidoylpyridin-2-yl)pivalamide (880 mg, 4.0 mmol) and dimethylmalonate (457 μL, 4.0 mmol) in 15 mL methanol is refluxed at 82° C. for 14 hours. The resulting suspension is dissolved in 15 mL water and acidified using 6M HCl. The precipitate is filtered, rinsed with water, air/vacuum dried and used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08173647B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-c8d47ea0ce384935902ec75606d14570 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
