HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,6-Trichloropyrimidine → HCID 59198389, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,6-Trichloropyrimidine | HCID 77378 | — |
| Reactant | 2-Aminopyrimidine-5-boronic acid, pinacol ester | HCID 17750212 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Product | HCID 59198389 | HCID 59198389 | 48% |
Reaction Steps
According to Method 5, the reaction of 2,4,6-trichloropyrimidine with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine in the presence of Pd(dppf)Cl2-CH2Cl2 in DME and 2 M Na2CO3 (3:1) gave 2,6-dichloro-4,5′-bipyrimidin-2′-amine in 48% yield. LCMS (m/z): 241.1 (MH+), Rt 2.05 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173647B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9ffe40cd748d4e549feaf3046bcde133 |
| Source note | uspto-grants-2012_05 |