Sodium Carbonate → HCID 59198408, compound

Participants

Reaction Steps

A mixture of N-(5-(4-chloro-6-morpholinopyrimidin-2-yl)pyridine-2-yl)pivalamide (50 mg, 0.133 mmol), 3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (94 mg, 0.399 mmol) and Pd(dppf)Cl2-CH2Cl2 (16 mg, 0.020 mmol) in 2 mL of dimethoxyethane:2 M Na2CO3 (3:1) is heated under microwave irradiation for 15 minutes at 130° C. (normal absorption, fixed hold time). The reaction mixture is partitioned between EtOAc (50 mL) and H2O (10 mL); the organic layer is separated, washed with brine (7 mL), dried over Na2SO4, filtered and concentrated. The residue thus obtained is used in the next step without further purification.

Provenance & Evidence