Cesium carbonate → HCID 59198407, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-6-morpholino-4,5′-bipyrimidin-2′-amine (10 mg), 3-amino-quinoline (9.8 mg), Pd(OAc)2 (1.5 mg), BINAP (6.3 mg), and cesium carbonate (15.5 mg) in THF (1 mL) was heated in a microwave at 110° C. for 10 minutes. The crude product was filtered and concentrated under reduced pressure. The product was purified by preparative HPLC to give 6-morpholino-N2-(quinolin-3-yl)-4,5′-bipyrimidine-2,2′-diamine. LCMS (m/z): 401.0 (MH+). Rt=1.83 min.

Provenance & Evidence