Triphenylphosphine → HCID 59448133, compound

Participants

Reaction Steps

To a solution of (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (378 mg, 2.0 mmol) in THF (7 mL) was added 3-hydroxy-5-methylisoxazole (200 mg, 2.0 mmol) and triphenylphosphine (629 mg, 2.0 mmol) at room temperature under an argon atmosphere. Then diethyl azodicarboxylate (˜40% in toluene, 1.1 mL, 2.5 mmol) was added and the reaction mixture was stirred for 3 h at room temperature. Concentration and purification by chromatography (silica, heptane:ethyl acetate=6:4 to 0:1) afforded the title compound (214 mg, 40%) as a colourless oil. MS: m/e=271.0 [M+H]+.

Provenance & Evidence