Hydrochloric Acid → HCID 87421083, compound

Participants

Reaction Steps

To a suspension of (diphenyl-phosphinoyl)-acetaldehyde example 1d (2.4 g, 9.0 mmol) and hydroxylamine hydrochloride (0.68 g, 10.0 mmol) in ethanol (50 mL) and water (100 mL) was added at 0° C. an aqueous solution of sodium hydroxide (50%, 5 mL) added dropwise within a 10 min period. After stirring at room temperature overnight, the resulting mixture was acidified with HCl (4 N). The mixture was then extracted with dichloromethane and the combined organic layers were then washed with water and brine and then dried over sodium sulfate, filtered and evaporated to afford the title compound (3.75 g, 98%) which was obtained as a light yellow solid. MS m/e (EI): 260.0 [M].

Provenance & Evidence