Ethanamine, 2,2,2-trifluoro- → 3-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

HRID 1920912ノート

反応式

HRID 1920912 の反応式
CO[C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[CH:6]=1)=[O:4].[F:24][C:25]([F:29])([F:28])[CH2:26][NH2:27]>>[F:24][C:25]([F:29])([F:28])[CH2:26][NH:27][C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[CH:6]=1)=[O:4]

参加物

3

反応物 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 674920483-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester

生成物 1

HCID 468970733-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide収率 64%

実験手順

As described for example 14e, 3-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester (100 mg, 0.32 mmol) was converted, using 2,2,2-trifluoroethylamine (38 mg, 0.38 mmol) instead of isopropyl amine, to the title compound (77 mg, 64%) which was obtained as a white solid after purification by chromatography (silica, heptane:ethyl acetate=4:1 to 1:4). MS: m/e=383.1 [M+H]+.

出典と根拠

ORDレコード
ord-7ce1417e4406445189f716a14b799fd4
出典データセット
uspto-grants-2012_05
特許番号
US08173652B2

反応ノート

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