反应详情

As described for example 14e, 3-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester (100 mg, 0.32 mmol) was converted, using 2,2,2-trifluoroethylamine (38 mg, 0.38 mmol) instead of isopropyl amine, to the title compound (77 mg, 64%) which was obtained as a white solid after purification by chromatography (silica, heptane:ethyl acetate=4:1 to 1:4). MS: m/e=383.1 [M+H]+.