1-Aminopiperidine → HCID 46897076, compound

Participants

Reaction Steps

As described for example 18, 3-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester (100 mg, 0.33 mmol) was converted, using 1-aminopiperidine (127 mg, 1.27 mmol) instead of N,N-dimethylhydrazine, to the title compound (83 mg, 68%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol=9:1 to 7:3). MS: m/e=384.2 [M+H]+.

Provenance & Evidence