Diisopropylethylamine → HCID 46897077, compound

Participants

Reaction Steps

To a solution of 3-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid (100 mg, 0.33 mmol) in DMF (5 mL) were added 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (160 mg, 0.5 mmol), N,N-diisopropyl ethyl amine (280 μL, 1.7 mmol) and N-aminopyrrolidine HCl (61 mg, 0.50 mmol). The resulting reaction mixture was for 4 h at room temperature. Concentration and purification by chromatography (silica, dichloromethane:methanol=1:0 to 8.5:1.5) afforded the title compound (70 mg, 57%) as a white solid. MS: m/e=370.2 [M+H]+.

Provenance & Evidence