2-Aminopropanol → 3-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid (2-hydroxy-1-methyl-ethyl)-amide

Participants

Reaction Steps

As described for example 24b, 3-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester (201 mg, 0.68 mmol), was converted using 1-hydroxymethylethylamine (62 mg, 0.82 mmol), instead of ethanolamine, to the title compound (142 mg, 62%) which was obtained as a colourless gum after purification by chromatography (silica, heptane:ethyl acetate=1:1 to 0:1). MS: m/e=338.5 [M+H]+.

Provenance & Evidence