反应详情

As described for example 28, 3-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester (377 mg, 1.28 mmol), was converted using 3-aminotetrahydrofuran (335 mg, 3.84 mmol), instead of isopropyl amine, to the title compound (368 mg, 82%) which was obtained as a colourless gum after purification by chromatography (silica, heptane:ethyl acetate=4:1 to 4:1). MS: m/e=350.4 [M+H]+.