N-Aminomorpholine → HCID 59448132, compound

Participants

Reaction Steps

As described for example 28, 3-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester (110 mg, 0.37 mmol), was converted using 4-aminomorpholine (153 mg, 1.5 mmol), instead of isopropyl amine, to the title compound (83 mg, 61%) which was obtained as a colourless oil after purification by chromatography (silica, dichloromethane:methanol=1:0 to 9:1). MS: m/e=365.3 [M+H]+.

Provenance & Evidence