Ethanolamine → 3-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isothiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide

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Reaction Steps

As described for example 36b, 3-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-isothiazole-5-carboxylic acid methyl ester (100 mg, 0.32 mmol), was converted, using ethanolamine (23 mg, 0.38 mmol), instead of isopropyl amine, to the title compound (90 mg, 82%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol=1:0 to 9:1). MS: m/e=345.2 [M+H]+.

Provenance & Evidence