Ethanamine, 2,2,2-trifluoro- → HCID 46897454, compound

Participants

Reaction Steps

As described for example 43 g, 3-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-isoxazole-5-carboxylic acid methyl ester (100 mg, 0.29 mmol) was converted, using 2,2,2-trifluoroethylamine instead of isopropylamine, to the title compound (25 mg, 21%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol=1:0 to 9:1). MS: m/e=414.0 [M−H]−.

Provenance & Evidence