Ethyl Bromide → HCID 16662498, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(6-phenyl-pyridazin-3-yl)-3,9-diaza-bicyclo[3.3.1]nonane free base (0.20 g, 0.71 mmol), bromoethane (0.059 ml, 0.78 mmol), N,N-diisopropylethylamine (0.18 g, 1.42 mmol) and dimethylformamide (5 ml) was stirred at 80° C. for 2 hours. Aqueous sodium hydroxide (20 ml, 1 M) was added and the mixture was extracted twice with diethylether (2×20 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the title compound as a crystalline solid. LC-ESI-HRMS of [M+H]+ shows 281.1761 Da. Calc. 281.176621 Da, dev. −1.9 ppm.

Provenance & Evidence