HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1920989Generated: October 29, 2026
Methylamine → N,1-Dimethyl-4-methoxy-1H-indol-2-carboxamide
https://huagongshe.com/reaction/1920989
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate | HCID 4777904 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N,1-Dimethyl-4-methoxy-1H-indol-2-carboxamide | HCID 22593784 | — |
Reaction Steps
A solution of methyl 4-methoxy-1-methyl-1H-indol-2-carboxylate (1.03 g, 4.7 mmole) in 2.0 M methylamine in methanol (40 mL) was sealed in a pressure bottle and heated at 55-60° C. for 60 hr. Concentration in vacuo yielded the title compound (1.05 g, quantitative) as a white solid: MS (ES) m/e 219.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08173646B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-011a9861012940fbb2bca3edf55f80bd |
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| Source note | uspto-grants-2012_05 |
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