反应详情

To a solution of 1.0 M BH3/THF (30 mL, 30 mmole) at 0° C. was added N-methylbenzofuran-2-carboxamide (1.75 g, 10 mmole). The reaction mixture was allowed to warm to RT, then was heated at reflux overnight. The reaction was cooled to 0° C. and excess methanol was added. The resulting solution was concentrated in vacuo and the residue was purified by flash chromatography on silica gel (3% MeOH/CH2Cl2). The tile compound (0.2 g, 12%) was obtained as a white solid: MS (ES) m/e 162 (M+H)+.

1. temperaturewas heated
2. temperatureat reflux overnight
3. temperatureThe reaction was cooled to 0° C.
4. concentrationThe resulting solution was concentrated in vacuo
5. customthe residue was purified by flash chromatography on silica gel (3% MeOH/CH2Cl2)