HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-Methyl-N-[(1-methyl-2-indolyl)methyl]acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | methyl((1-methyl-1H-indol-2-yl)methyl)amine | HCID 11401058 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Methyl-N-[(1-methyl-2-indolyl)methyl]acrylamide | HCID 20752825 | — |
Reaction Steps
To a solution of 1-methyl-2-(methylaminomethyl)indole (0.78 g, 4.5 mmole), from Preparation 1, and triethylamine (1.4 mL, 10.0 mmole) in CH2Cl2 (50 mL) at 5° C. was added acryloyl chloride (0.41 mL, 4.95 mmole). After 45 min, the reaction solution was poured onto H2O and the layers were separated. The organic phase was dried over Na2SO4 and concentrated to afford the title compound as a yellow oil. This was used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173646B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ba37fa5c06564dc3991eb910b1604a72 |
| Source note | uspto-grants-2012_05 |