HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-Methyl-N-[(1-methyl-2-indolyl)methyl]acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | methyl((1-methyl-1H-indol-2-yl)methyl)amine | HCID 11401058 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Methyl-N-[(1-methyl-2-indolyl)methyl]acrylamide | HCID 20752825 | — |
Reaction Steps
To a stirred solution of 1-methyl-2-(methylaminomethyl)-1H-indole (13 g, 8.6 mmole) and Et3N (1.35 mL, 9.6 mmole) in CH2Cl2 (75 mL) at 0° C. was added dropwise acryloyl chloride (0.77 mL, 93 mmole) over 5 minutes. After 2 h the reaction was washed with cold H2O, brine, dried (MgSO4) and concentrated under vacuum. The residue was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173646B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4f45d389663b46ba887ae2742122d8cd |
| Source note | uspto-grants-2012_05 |