HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2',4-Dioxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 58026277 | HCID 58026277 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (2',4-Dioxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl)acetic acid | HCID 59708346 | — |
Reaction Steps
HCl (g) was bubbled into a solution of tert-butyl (2′,4-dioxospiro[cyclohexane-1,3′-indol]-1′(2′H)-yl)acetate from Step B (800 mg, 2.43 mmol) in EtOAc (10 mL) for 5 min. After 3 h, the reaction was concentrated in vacuo to give the desired product. MS: m/z=274 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173655B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-af4bb21f96554dac8678a2cd576f577f |
| Source note | uspto-grants-2012_05 |