Water → HCID 67337039, compound

HRID 1921213Notes

Reaction equation

[OH-].[Na+:2].[Br:3][C:4]1[CH:5]=[C:6]2[C:12]3([CH2:17][CH2:16][S:15][CH2:14][CH2:13]3)[C:11](=[O:18])[N:10]([CH2:19][C:20]([O:22]CC)=[O:21])[C:7]2=[CH:8][CH:9]=1.O>CCO>[Br:3][C:4]1[CH:5]=[C:6]2[C:12]3([CH2:17][CH2:16][S:15][CH2:14][CH2:13]3)[C:11](=[O:18])[N:10]([CH2:19][C:20]([O-:22])=[O:21])[C:7]2=[CH:8][CH:9]=1.[Na+:2]

Participants

Conditions

Temperature: 60 °C

Procedure

5 M Sodium hydroxide solution (0.748 mL, 3.74 mmol) was added to a solution of ethyl (5-bromo-2-oxo-2′,3′,5′,6′-tetrahydrospiro[indole-3,4′-thiopyran]-1(2H)-yl)acetate from Step D (479 mg, 1.25 mmol) in EtOH(2 mL) and the mixture was heated to 60° C. After 14 h, H2O (5 mL) was added to the reaction and the resulting precipitate was collected by filtration to give the desired product. MS: m/z=357 (M+1).

Workup

filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record: ord-06241e0c74fb4325ae963cef27b402c4
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173655B2

Reaction notes

Loading…