Triethylamine → HCID 178513362, compound

Participants

Reaction Conditions

Reaction Steps

517 mg 4-[5-(4-trifluoromethyl-phenyl)-2,3-dihydro-indole-1-sulfonyl]-benzonitrile were dissolved in a mixture of 10 ml tetrahydrofuran and 10 ml methanol. 1.68 g hydroxylamine hydrochloride were added followed by the addition of 3.35 ml triethylamine. The reaction mixture was stirred at 65° C. for eight hours. The solvents were removed in vacuo and the resulting residue poured into water and extracted five times with ethylacetate. The combined organic extracts were washed with brine, dried over MgSO4 and the solvent was evaporated in vacuo to obtain 550 mg N-hydroxy-4-[5-(4-trifluoromethyl-phenyl)-2,3-dihydro-indole-1-sulfonyl]-benzamidine as an oil. C22H18F3N3O3S (461,47), MS (ESI): 462.2 (M+H+).

Provenance & Evidence