HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1921263Generated: October 31, 2026
Sodium Bicarbonate → HCID 178510911, compound
https://huagongshe.com/reaction/1921263
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Boron tribromide dichloromethane | HCID 22277759 | — |
| Reactant | HCID 178487482 | HCID 178487482 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178510911 | HCID 178510911 | 51% |
Reaction Steps
3-cyclohexyl-2-(6-methoxy-1H-indazol-3-yl)propanenitrile (1.61 g, 5.68 mmol) was dissolved in CH2Cl2 and cooled with an ice bath. BBr3/CH2Cl2 1M (8.6 ml, 8.52 mmol) was added to this mixture, which was stirred at 50° C., then poured onto saturated NaHCO3 solution, extracted with ethylacetate, dried over Na2SO4, filtered, concentrated under vacuum and purified by flash chromatography (CH2Cl2/MeOH 98/2). Crystallisation from EtOH gave 780 mg of white crystals (51%). mp 175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08173679B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-6cb85c0ce6ef4f0ca0d1d3ef701b6bcc |
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| Source note | uspto-grants-2012_05 |
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