Nitrogen → HCID 23117115, compound

Participants

Reaction Steps

1-adamantyl-(4-benzyloxy-2-fluorophenyl)methanone oxime (2.3 mg, 6 mM) in DMF (30 ml) was added at 0° C. dropwise under N2, to a stirred suspension of NaH (0.61 g, 18 mM, 60% oil dispersion) in DMF (10 ml). After the complete addition, the reaction mixture was allowed to warm to room temperature and poured into H2O. The precipitate was collected by filtration to give the expected product (2.06 g, 95%). mp 132° C.

Provenance & Evidence