HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 86639848, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 61728956 | HCID 61728956 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86639848 | HCID 86639848 | 94.9% |
Reaction Steps
To a suspension of 1-(2,6-difluorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid (795 mg) in CH2Cl2 (8 mL) were added DMF (0.025 mL) and ethanedioyl dichloride (603 mg) at 0° C. under a nitrogen atmosphere, and the mixture was stirred at room temperature for 2 hr. The volatile materials were removed by evaporation in vacuo to give 1-(2,6-difluorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarbonyl chloride (810 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173684B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-6ab7fa7a02a54e26a67a4ebe00d129c1 |
| Source note | uspto-grants-2012_05 |