HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1921297Generated: October 30, 2026
1-Bromo-2-methylpropane → HCID 67217327, compound
https://huagongshe.com/reaction/1921297
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-2-methylpropane | HCID 6555 | — |
| Reactant | 3-Isoxazolamine, 5-(1,1-dimethylethyl)- | HCID 171473 | — |
| Product | HCID 67217327 | HCID 67217327 | 61.9% |
Reaction Steps
A mixture of 5-tert-butylisoxazol-3-amine (3.0 g, 21 mmol) and 1-bromo-2-methylpropane (3.5 mL, 32 mmol) was warmed to 85° C. and was allowed to stir for 70 h. The mixture was cooled to ambient temperature and was purified by column chromatography (silica gel, 60% hexanes/EtOAc) to give the title compound (2.5 g, 13 mmol, 60% yield). MS (DCI/NH3) m/z 197 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08173687B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-eec772c65ba94603b501b78b81e629ac |
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| Source note | uspto-grants-2012_05 |
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