4-(Trifluoromethyl)benzylamine → HCID 11712212, compound

HRID 1921384Notes

Reaction equation

HRID 1921384 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[F:20][C:21]([F:31])([F:30])[C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>>[F:20][C:21]([F:30])([F:31])[C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH:27][S:16]([C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 11712212HCID 11712212, compoundYield 44%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 4-trifluoromethylbenzylamine as described in Step 5, Example 24 to give the title compound as a solid (44% yield). LC/MS: RT 3.80 min; m/e 457 (M+H).

Sources & evidence

ORD record
ord-fc71886cb5d94a80849b6588943e72e3
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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