1-Benzyl-4-piperidylamine → HCID 11533543, compound

HRID 1921396Notes

Reaction equation

HRID 1921396 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH2:20]([N:27]1[CH2:32][CH2:31][CH:30]([NH2:33])[CH2:29][CH2:28]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[ClH:19].[CH2:20]([N:27]1[CH2:32][CH2:31][CH:30]([NH:33][S:16]([C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])[CH2:29][CH2:28]1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 4158521-Benzyl-4-piperidylamineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 11533543HCID 11533543, compoundYield 80%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride was reacted with (1-benzylpiperidin-4-yl)amine as described in Step 5, Example 24 to give the title compound as a solid (80% yield). LC/MS: RT 2.27 min; m/e 472 (M+H).

Sources & evidence

ORD record
ord-37fa65cfe0a34abaa32f9513eac52281
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

Loading…